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So the deal was And then a week later, they make this announcement and the stock roars and, you know, everyone goes, oh, congrats, Hims
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these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1
These include methionine synthase, betaine homocysteine transferase, and methionine adenosyltansferase, which are redox-sensitive enzymes and are down-regulated by oxidative stress