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BDNF knockdown experiments further cement its role: mice with conditional BDNF deletion in the ventral tegmental area (VTA) or hippocampus develop spontaneous depressive phenotypes, even in the absence of ethanol, while BDNF infusion into these regions rescues ethanol-induced anhedonia (Zhong et al

Intraperitoneal insulin delivery to patients with type 1 diabetes results in higher serum IGF-I bioactivity than continuous subcutaneous insulin infusion

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They also were associated with risk factors for reproductive, neurological, renal, respiratory, hematopoietic, skin, cardiovascular, immunological and developmental issues

the American Diabetes Association