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Benefits are based on preliminary research and clinical use cases

By suppressing NNMT, it boosts NAD+ levels, enhances cellular energy production, and improves metabolic rate

61 In practice, some patients may be able to switch to very high dose (ie, 2000 mcg daily) oral supplementation instead of continuing parenteral administration, but it is impossible to predict in whom this can be done safely, and many are at risk of worsening symptoms which may become permanent

How is the research typically conducted

These areas (upper arms, outer-upper thighs, and belly area) have fewer blood vessels than muscle, which allows nutrients to absorb more slowly and consistently over time