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STAT3 hyperactivation promotes cellular proliferation, survival as well as immunosuppression by promoting VEGF, IL-6, IL-10 and TGF-

In some embodiments, the otoprotectant is any one of the following compounds: In some embodiments, the otoprotectant is an antioxidant

Research in animal models shows activity at approximately 0.5mcg/kg, though human protocols typically use standardized doses in the 1-3mg range regardless of body weight