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In apoptosis, -sitosterol upregulates pro-apoptotic factors such as p53 and Bax, while downregulating anti-apoptotic proteins such as Bcl-2, leading to an increase in mitochondrial outer membrane permeability and the activation of key apoptotic enzyme cascades such as caspase-9 and 3, which induces programmed cell death (83)

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J Biol Chem 289(32):2204822062 Chauhan A, Islam AU, Prakash H, Singh S (2022) Phytochemicals targeting NF-B signaling: potential anti-cancer interventions

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