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If they occur, stop the compound and seek medical evaluation immediately

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Preoperative modifiable risk factors in colorectal surgery: an observational cohort study identifying the possible value of prehabilitation

These hydroxylation reactions also require Fe 2+ as a cofactor, O 2 as a cosubstrate and ascorbic acid (vitamin C) as a reductase, which restore the activity of 2-OGDD enzymes (Fig