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The enzymatic activity of ERO1 can be controlled through a negative feedback regulation mechanism to prevent ER peroxidation [106]

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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

1 The standard treatment for a positive diagnosis of NAFLD is lifestyle modification

Reconstitution for injectable use requires bacteriostatic water containing 0.9% benzyl alcohol as an antimicrobial preservative