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Mitochondrial (Dys) function in inflammaging: do mitomirs influence the energetic

Tan, S., Khumalo, N

Although small molecule or peptide-based inhibitors against individual NSPs have been extensively explored in the past 50 years, efforts of the pharmaceutical industry so far have created little impact in the clinic, except for AAT augmentation therapy in patients with emphysema and congenital AATD (191)

Cysteine restriction promotes an iron-dependent form of cell death known as ferroptosis 7 , where Fenton chemistry promotes the generation of free radicals that initiate lipid radical formation and the unsustainable peroxidation of plasma membrane phospholipids 8