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Moreover, their interaction with membraneassociated receptors, such as prion proteins and spectrin, further exacerbates oxidative stress, elevates ROS levels, reduces ATP production, and disrupts cytoskeletal dynamics [156, 157, 158]

The establishment and preservation of the BBB are intricate cooperative processes, hinging on the synergistic actions among the constituent cells of the neurovascular unit (NVU)endothelial cells (ECs), pericytes, astrocytes, extracellular matrix, and neurons (Fig

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Furthermore, both aqueous and alcoholic extracts derived from M