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Because Parkin and GluK2 co-immunoprecipitate and Parkin ubiquitinates GluK2, the loss of Parkin function leads to GluK2 accumulation in the cell membrane [63]

FIGURE 1 5 Multiple cell ferroptosis promotes atherosclerosis 5.1 Ferroptosis of vascular endothelial cells promotes atherosclerosis AS begins with vascular endothelial dysfunction, characterized by increased permeability, leukocyte adhesion, heightened inflammation, and accelerated plaque and thrombus formation

[CrossRef] [PubMed] [Google Scholar] Antioxidants in reproductive health and fertility Berlin: Springer International Publishing AG