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Redox imbalance in age-related diseases In the last few decades, several models have been suggested to define the interconnection and the biological pathways of aging (Dice, 1993)

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GH/IGF-1 transgenic mice Transgenic mice overexpressing human, bovine or rat GH genes exhibit excessive GH and IGF-1 concentrations resulting in a giant phenotype and organomegaly, including increased kidney weight even when related to increased body weight (Fig

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