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Whilst some forms of chemical degradation are not detectable by the naked eye, several observable changes can indicate that a solution has deteriorated and must not be used

The depletion of glutathione (an antioxidant needed to remove the cyanide from cyano B12) may increase homocysteine, thus only making things worse for these patients

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GHK-Cus mechanism depends on gradual tissue accumulation over the cycle, not on high single-day concentrations