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What the research points to An interesting scientific idea helping neurons form new connections rather than just stimulating them Improved memory task performance in rats and mice, including Alzheimer's model mice Synapse growth in cultured brain cells A reason some researchers considered the angiotensin IV pathway worth pursuing What it does NOT prove That it improves memory or cognition in any human this has never been tested That it's safe in humans at any amount, for any duration there is no human safety data That its proposed brain mechanism is established the key paper was retracted in 2025 That it's an approved treatment for Alzheimer's or anything else it is not approved anywhere Who talks about it and why to be careful Dihexa is heavily promoted in nootropic and biohacking circles, and the search results for it are dominated by people selling it

doi: 10.1016/S0896-6273(02)00722-5