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Insulin syringe reference (U-100): 1 IU = 50 mcg 100 mcg = 2 IU (0.02 mL) 500 mcg = 10 IU (0.1 mL) 1,000 mcg = 20 IU (0.2 mL) Typical research scheduling: Daily subcutaneous or intramuscular administration is commonly studied

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Despite increased glucose uptake, 13 C-labeling of lactate from [U- 13 C]glucose was markedly diminished in IDH1/ cells (Extended Data Fig

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