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Alcohol combined with cerulein (CI) exerts direct damage to pancreas, with its mechanism undefined

More recent evidence revealed an endothelial-cell-instigated Notch-mediated pathway in perivascular sub-lining synovial fibroblasts, that establishes a positional gradient for sub-lining synovial fibroblasts differentiating to lining synovial fibroblasts [31]

Treatment usually lasts between 30 to 60 minutes

Preventive measures include adjusting fluid intake according to thirst and alternating alkaline water with electrolyte balanced solutions during prolonged exercise or heat exposure

Given the heterogeneity of NPCs, we further analyzed the scRNA-seq data (GSE165722) 26 from human NP tissues with mild (grades II and III) and severe (grades IV and V) degeneration to identify the potential pathogenic factors associated with IDD