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It may be considered in refractory cases but carries risks of dependence and adverse effects

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Introduction Although nitric oxide (NO) has been posited as a deleterious molecule from a physiological perspective ( In the context of exercise, nitrate supplementation has gained interest as an ergogenic aid to enhance endurance performance ( Therefore, the purpose of this review is to present the general knowledge of the underlying physiological mechanisms affected by NO and the subsequent effect of nitrate supplementation in exercise

Neurotrophic and anti-inflammatory effects (days to weeks) Semax elevates BDNF within hours, but the downstream effects of that elevation, including new synaptic connections, improved neurotransmitter signaling, and reduced inflammatory gene expression, unfold over days and weeks

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