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In some embodiments, the otoprotectant is a compound of Formula (XI) having the structure of Formula (XIa): In some embodiments, the otoprotectant is any one of the following compounds: or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate or hydrate, pharmaceutically acceptable salt hydrate, or pharmaceutically acceptable prodrug thereof

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They improve sleep quality, especially deep, restorative sleep, which enhances memory, focus, and overall brain function

Consequently, individuals with increased body fat generally exhibit elevated leptin levels [52]

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