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As described in section A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS, GABA release from interneurons, both via neurotransmission and reverse transport, has a strong influence on the excitability of glutamatergic neurons

All research must be conducted under appropriate ethical oversight, institutional review board approval, and regulatory compliance with applicable research standards

doi: 10.1016/j.jsbmb.2021.105823 78 MushtaqFAkhtarMFSaleemASharifAAkhtarBAskaryAEet al

This reflects the inability of the cell to carry and generate mitochondria