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Moreover, the rate at which telomeres shorten is accelerated by inflammation, oxidative stress, nutritional deficiencies, genetic predisposition, and other lifestyle habits such as smoking, recreational drug use, alcohol use and exposure to toxic chemicals and moulds

So if you have the MTHFR gene variation, or are thinking of testing for it, I hope that this overview empowers you

10.1186/s12915-014-0056-6 BMC Biol

(2) Targeting Hemoglobin S Polymerization Approaches targeting HbS polymerization presents a very attractive strategy as this puts out the fire rather than dealing with the sequelae of the sickling event (Eaton and Bunn, 2017)