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The Kyn/Trp ratio was also directionally higher in symptomatic patients than in asymptomatic V30M carriers, although this comparison did not reach statistical significance in the two-tailed analysis ( p = 0.0594)

Ramana KV, Yadav UC, Calhoun WJ, Srivastava SK

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Its rapid degradation by circulating proteases produces a short, discrete stimulus to the pituitary gland that closely mirrors endogenous growth hormone-releasing hormone GHRH pulsatility