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Using in vivo experimental models, they revealed that astrocyte-derived cytokines may induce secretion of S100A9 by cancer cells, thereby activating the RAGE pathway and resulting in radioresistance in an NF-kB/JunB-dependent manner

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With regards to the interactions of TrxR1 with juglone (walnut toxin), which is a defining characteristics of SecTRAPs (see we discovered that the C-terminal Cys residue of TrxR1, neighboring the Sec residue, is of major importance