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2013;1:E7782
This finding raises a question regarding the use of animal models that are merely a phenocopy of human NASH, as humans do not normally develop NASH due to the rare autosomal recessive Alms1 mutation (Marshall et al., 2011)
However, the relatively limited number of clinical trials on synbiotic therapies in IBS patients have thus far produced varying results which could be due to the different probiotic and prebiotic components used in different trials, as well as the different subsets of IBS patients studied ( It is interesting to note that an open, uncontrolled, multicenter study involving 43 centers focused on 636 IBS constipation-predominant patients who were given a synbiotic composed of Bifidobacterium longum W11 and the short chain oligosaccharide prebiotic Fos Actilight, had reported significant improvements in stool frequency, bloating and abdominal pain ( Bifidobacterium lactis was associated with significant improvement on IBS symptoms and bowel habit vs
