indeed, Low SHBG is linked to impaired glucose homeostasis, altered lipid profiles, reduced testosterone levels, and increased risk of metabolic syndrome, T2DM, gestational diabetes mellitus (GDM), and cardiometabolic complications often independent of traditional cardiovascular risk factors
Vegans, vegetarians, people over the age 50, anyone with stomach/bowel issues like chronic gastritis, leaky gut, IBS or celiac, and anyone who regularly takes medications such as Metformin, PPIs (used for GERD), H2 Receptor Antagonists (used for peptic ulcers), or anything that interferes with stomach acid production are actually at risk for vitamin B12 deficiency, and should supplement B12 regularly
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Once inside the enterocytes, B12 is released from intrinsic factor and binds to transcobalamin II, forming holotranscobalamin, the biologically active form that enters the bloodstream
