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Both the oxidation of nutrients in the mitochondria and the oxidation of nascent proteins in the ER generate toxic reactive oxygen species (ROS): in the mitochondria by electron leakage during oxidative phosphorylation (Murphy, 2009), and in the ER by catalysis of disulfide bond formation by ER oxidoreductase (ERO1) (Higa & Chevet, 2012)

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Final Moments and Postmortem Though cardiac arrest is suspected, the official cause of death remains pending until postmortem results are reviewed