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For laboratories conducting in vitro or specialized in vivo studies requiring liquid solution: Diluent: Use deionized water or a physiological saline solution for solubility

Therefore, even though B12 may come in more concentrated dosages with oral administration, the IM shots still provide the best way to correct B12 deficiency

Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

For anyone struggling to keep food or supplements down during illness, IV delivery removes the absorption barrier that makes oral intake unreliable

Journal of physiology and pharmacology: an official journal of the Polish Physiological Society, 60 Suppl 7 , 115122