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doi: 10.2147/DDDT.S82030

Estrada LV, Barcelona V, Dhingra L, et al

In heart failure and cardiomyopathy, the number of mast cells is greatly increased.[ref] Atrial fibrillation (a-fib) is a heart arrhythmia that includes rapid atrial activation and an irregular response in the ventricle

However, Gepon did not significantly affect the levels of these anti-inflammatory mediators, suggesting its primary mechanism was suppression of pro-inflammatory signaling rather than enhancement of anti-inflammatory pathways