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doi: 10.3389/fphar.2026.1780815 Received 04 January 2026 Revised 30 March 2026 Accepted 30 April 2026 Published 05 June 2026 Volume 17 - 2026 Edited by Galina Sudina, Lomonosov Moscow State University, Russia Reviewed by Shangkun Ou, Affiliated Hospital of Guizhou Medical University, China Hyeongjwa Choi, Chungnam National University Hospital, Republic of Korea Updates Copyright 2026 Gallo Afflitto, Fanelli, Petrone, Chirico, Ceccarelli, Martucci, Minutolo, Aiello, Garaci, Matteucci and Nucci

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Introducing a compound with a known and directly opposing mechanism of action is poor protocol design

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