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Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)

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Biological Role of Vitamin B12 Helps make red blood cells Prevents certain types of anemia Keeps nerves protected Supports memory and focus Helps turn food into energy B12 deficiency may lead to fatigue, shortness of breath, nerve damage, memory impairment, mood changes, and irreversible neurological complications if untreated