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Children: mild to moderate side effects were reported in children in a small pilot study, although authors defined 200mg/kg/day as a well-tolerated dose among children of mean age 5 years (Goin-Kochel 2019)

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Yes, even one incident can cause irreversible liver scarring

Diltiazem, a calcium channel blocker, has been shown to protect mitochondrial function and reduce oxidative stress in cardiovascular diseases [524, 525]