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NAD+ serves as an essential coenzyme in the mitochondrial electron transport chain and as a critical substrate for sirtuins, PARPs, and CD38-type enzymes involved in DNA repair, stress resistance, and metabolic homeostasis

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Observed adverse events such as myalgia and headaches were classified as mild to moderate and assessed as unrelated to the interventions.20 This means that researchers ultimately determined that the headaches and muscle pain experienced by patients during the studies were not due to urolithin A supplementation