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Implemented dietary supplementation with microbe-derived antioxidants induced beneficial biochemical changes in plasma parameters [83] without any negative clinical effects in healthy Beagle dogs

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Concentrations of the peptide up to 500 ng/mL failed to increase proliferation of mouse C2C12 cells or primary human skeletal muscle myoblasts, failed to inhibit myoblast differentiation, and failed to activate the signaling responses previously attributed to it, even as mature IGF-1 and full-length IGF-1Eb produced robust responses in the same assays