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In models of cerebral hypoxia-ischemia, an increase of DNA methylation was described as an increase in global DNA methylation in the murine cerebral hemispheres, in the promoter of tissue inhibitors of MMP-2 (TIMP2)

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[4] Why Vitamin B12 Can Cause Gastrointestinal Symptoms The mechanisms underlying gastrointestinal side effects from vitamin B12 supplementation are not fully established, but several factors may contribute to stomach discomfort in susceptible individuals