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What's missing: No human pharmacokinetic data No human safety data No optimal dose for humans (mouse 20mg/kg = ~150mg in a 75kg human if dose-equivalent, but mouse-to-human scaling for small molecules is unreliable) No drug interaction data No long-term safety data Buyers in this category are doing biohacker-tier self-experimentation with limited data

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The Short-Term Timeline: Days 3 to 7 By the end of the first week, the initial surge settles into a steadier supply of B12, and this is often when the more noticeable day-to-day changes appear

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Generally yes, but patch test for sensitive skin