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First of all, antioxidant selenoenzymes are often in the spotlight, including GPXs types I-IV and VI (GPX1-4, 6), thioredoxin reductases type I-III (TXNRD1-3), and methionine sulfoxide reductase B (MrsB) (Arner and Holmgren, 2000

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By controlling the activity of downstream targets, the PI3K signaling pathway influences the secretion of inflammatory cytokines by cells of the innate immune system