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157 We posit that for high affinity metals, notably Cu II (and Cu I ), Zn II and Ni II , affinities are so tight so as to render metal dissociation rates (off-rates), even if increased by the presence of metal-buffering small molecules, far too slow to be relevant during intermolecular metal transfer (Figure 34, top )

With 2 mL of water and a 1 mg daily dose (4 units), the vial lasts 50 days

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