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However, in the process of active penetration, the cAMP/PKA signaling pathway activates the expression of hypha-related genes through Efg1, a process that is considered necessary for active penetration and epithelial cell damage (Rai et al., 2021)

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The elevated levels of oxidative stress in GDM placenta originated from an imbalance between the production of ROS and the antioxidant defence system [21]