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Baseline inflammatory markers, including C-reactive protein and interleukin-6, can provide an objective reference point for assessing systemic anti-inflammatory effects where that is a stated goal

The possible reason Frontiers in Bioengineering and Biotechnology | www.frontiersin.org 7April 2021 | Volume 9 | Article 677576 fbioe-09-677576 April 24, 2021 Time: 18:16 # 8 Huang et al

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Opioids (heroin) predominantly target the brains reward system, leading to microglial activation and oxidative stress