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Figure 3 3.4 Epigenetic and signal transduction effects The regulation of epigenetics and the manipulation of signal transduction pathways have emerged as a fundamental mechanistic basis by which natural agents can exert strong anti-cancer effects in breast cancer, affecting the various stages of tumour development (initiation, progression, metastasis), and response to therapy by targeting diverse interactions between gene expression, chromatin structure, and intracellular signalling elements (198)