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Physiol Rev 83 : 10171066

10.1016/S0140-6736(14)60222-1 Lancet

Sterile syringes, needles, alcohol swabs, and a sharps container may be required if injections are given at home

Acknowledgements Bioacme Biological Technologies Corporation (Wuhan, China) provided the support on transcriptome sequencing

While the applicant states that SPEVIGO will be the first GPP treatment targeting the IL-36 pathway, we note that per the applicant, other treatments are available and we therefore question whether placebo is the most appropriate comparator