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The benefits of this reaction to cancer cells are ATP produced by substrate-level phosphorylation, i.e., no OXPHOS required, while 3-phosphoglycerate may also serve as a precursor for serine and glycine synthesis

1 H NMR (300 MHz, DMSO) 8.26 (d, J = 7.6 Hz, 1H), 7.45 7.34 (m, 9H), 7.25 (d, J = 1.4 Hz, 1H), 7.13 7.03 (m, 6H), 7.03 6.95 (m, 1H), 6.70 6.61 (m, 1H), 4.49 (q, J = 6.9 Hz, 1H), 3.54 (s, 3H), 3.52 (d, J = 5.9 Hz, 1H), 2.82 (dd, J = 6.7, 3.4 Hz, 2H), 1.35 (s, 9H)

Although these findings were observed in non-CRC models, they are highly relevant to CRC, where hypoxia-driven chemoresistance remains a significant challenge (141)

Introduction Chronic kidney disease (CKD) is defined by abnormalities in kidney structure or function and is characterized by permanent nephron loss and an eventual decline in the glomerular filtration rate (GFR) (Zalups and Diamond, 1987)

Understanding these differences helps set realistic expectations and supports smarter skincare decisions