Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
Whether the delivered amount crosses the threshold for therapeutic effect in any given individual also remains unknown
Next steps for researchers: review the product COA, run a brief pilot to confirm dosing and assay compatibility, and document storage and handling for every lot to protect data integrity
This reduces oxidative stress and replenishes living cells
Podcasts, optimisation channels and health influencers played a huge role in exposing more people to concepts that previously felt extremely niche
