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Materials and methods Ethic statements The animal studies were carried out in strict accordance with the Detailed Rules for the Administration of Animal Experiments for Medical Research Purposes issued by the Ministry of Health of the Peoples Republic of China and were approved by the Animal Experiment Administration Committee of The Fourth Military Medical University

Oxidative stress, which destroys cells and impairs bodily function, can be brought on by free radicals

This makes it easier

The subcutaneous tissue at that site becomes sensitised, and subsequent injections into the same area are progressively more uncomfortable

These receptors have been identified to show specific tissue expression patterns and binding affinities for each of the melanocortin hormones