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The presence of numerous risk factors should be a stimulus for an extended diagnostic workup

29 : 569574 De Simone C, Calvani M, Catania S, Trinchieri V, Di Fabio S, Santini G et al

Genetics of homocysteine metabolism and associated disorders

Future research priorities should include the design and execution of adequately powered, controlled clinical trials that systematically account for interspecies pharmacokinetic variation, disease stage, comorbid conditions, and potential breed-specific metabolic differences

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