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G6PD variants associated with hemolysis result in misfolding of the protein, making it more susceptible to proteolytic degradation

In this sense, some Turkish populations have been traditionally consuming high amounts of hot chili pepper (capsaicin) in food and it has been observed a high incidence of epilepsy in these areas (unpublished data)

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In addition, the use of CAT inhibitor during the pre-hypertensive stage might further elucidate the role of elevated CAT in the pathogenesis of hypertension in this species, although melatonin supplementation during the antenatal and postnatal period was found to significantly increase CAT expression and activity and delay the rise in blood pressure in hypertensive rats