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Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes

also reported LPA (18:1) inhibits serum deprivation-induced autophagy in PC-3 cells (71)

It also does not provide the direct group comparison with other treatment groups, including patients that received guanfacine/NAC or donepezil/NAC only combinations

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