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Therefore, we optimized the model transition state for methanethiolate oxidation at the B3LYP/6-31 G* level with the Jaguar (version 10.4) software package 59 and verified the first-order saddle point nature of the transition state with a frequency calculation at the B3LYP/6-31 G* level

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Moreover, we highlight the therapeutic potential of targeting lactylation in treating brain disorders and outline key research gaps and future directions needed to advance this promising field