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Although the NADPH-dependent disulfide reductase YpdA has been proposed to catalyze the regeneration of BSH, experimental evidence still needs to be provided [50]

Opstelten, D

Moreover, studies using animal models where gut permeability is altered because of the direct or indirect genetic or pharmacological manipulations have demonstrated diverse effects on mucosal immune homeostasis and inflammation, including immune adaptation and resistance to colitis

Actually, only Pexiganan and Omiganan show a significant effectivity compared to conventional antibiotics in the third phase of clinical trials