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However, another group found that the presence of the T1D-linked genetic variant of rs2281808 is associated with reduced SIRP expression in CD8+ T cells, an increased effector state with a lower T cell activation threshold, and a reduction in gene expression associated with long-term functional memory T cell formation (84)

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Its also involved in synthesizing fatty acids and myelin via its role as a co-enzyme (2)

In PD pathology, ASC specks are considered hallmarks of pyroptosis, as their expression has been observed in peripheral blood mononuclear cells, and this exacerbation is sufficient to enhance NLRP3 inflammasome formation (Fan et al., 2020