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Due to the cardiac muscles severely diminished innate capacity for regeneration, catastrophic coronary artery disease like infarction of the myocardium (MI) currently lacks an appropriate therapy

doi: 10.1007/s11033-022-07757-8 85 NiknamMMalekiMHKhakshourniaSRasouliMVakiliOShafieeSM

Delivering B12 by injection bypasses absorption issues that limit how well oral supplements work for some patients

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If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy