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If the level of colchicine builds up too high, as it might if a usual dose is given to a patient with severe kidney disease, toxicity can occur, such as suppression of the production of blood cells

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doi: 10.1016/S1474-4422(14)70305-9 67 ShevachEMChangJTSegalBM

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Unknown long-term profile: No human safety data, so caution and monitoring are advised